The Stamets Protocol: Psilocybin, Lion’s Mane & Niacin Explained

If you’ve spent any time in the microdosing world, you’ve almost certainly heard the name Paul Stamets. And if you’ve heard his name, you’ve almost certainly heard about the Stack.

The Stamets Protocol — a specific combination of psilocybin, Lion’s Mane mushroom, and niacin — has become one of the most talked-about and debated routines online. Meet Da Mushies explains the popular framing: Lion’s Mane for neurotrophic interest, niacin for the flush/distribution story people repeat, and psilocybin as the psychoactive component in jurisdictions where it is lawful.

Evidence quality varies by claim. Functional mushrooms like Lion’s Mane are part of our legal catalog conversation; psilocybin remains tightly regulated. Do not treat internet protocols as medical plans.

Talk to a clinician before stacking supplements or considering any restricted compound.